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CARDIOLOGY ONLINE NEWS |
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| 21st WORLD CONGRESS ON HEART DISEASE |
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THE PRESENT AND FUTURE OF THE TOTAL ARTIFICIAL HEART
Francisco Arabia, M.D., Cedars-Sinai Medical Center, Los Angeles, CA, USA
We aim to better understand the pt population with biventricular failure receiving TAH as a BTT, determine outcomes in 3 eras, effect of implanting ctr on outcomes, and adverse events related to this therapy. MORE» |
2016 UPDATE ON TREATMENT OF HYPERTENSION
 Wilbert S. Aronow, M.D., Westchester Medical Center/New York Medical College, Valhalla, NY, USA
Numerous guidelines from 2011 through 2015 except for JNC 8 recommended that the blood pressure (BP) goal should be <140/90 mm Hg in persons younger than 80 years and <150 mm Hg in persons 80 years and older. JNC 8 recommended that the BP goal should be <150/90 mm Hg in persons 60 years and older without diabetes or chronic kidney disease. MORE» |
DELIRIUM IN THE INTENSIVE CARE UNIT: MORE THAN A NUISANCE
Gregory W. Barsness, M.D., Mayo Clinic, Rochester, MN, USA
Regardless of the underlying condition and comorbidities, along with pain and agitation, delirium is a common condition with major impact on the care and outcome of patients requiring intensive care unit (ICU) hospitalization. MORE»
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ACELLULAR BIOLOGICS FOR CARDIAC REGENERATION
Atta Behfar, Ph.D., Mayo Clinic, Rochester, MN, USA
The global drive to generate new curative therapies is fueled by a growing unmet perpetuated by the heart failure pandemic. Regenerative trials in cardiovascular disease have focused on the use of cell-based therapy in acute myocardial injury, in order to halt progression towards heart failure, or in congestive heart failure, to regenerate a deteriorating myocardium. MORE» |
PET AND CT ASSESSMENT OF CORONARY FLOW PHYSIOLOGY
Daniel S. Berman, M.D., Cedars-Sinai, Los Angeles, California USA
Assessment of fractional flow reserve (FFR) and coronary flow reserve by invasive coronary angiography provide physiologic assessments that complement the anatomic assessment of coronary stenosis for guiding patient management of patients with coronary artery disease. MORE»
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CONTROVERSIES IN ANTIPLATELET AND ANTICOAGULANT THERAPY
Deepak L. Bhatt, M.D., Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Antiplatelet therapy is critical for patients with acute coronary syndromes, those undergoing coronary stenting, and especially for patients with both indications. Aspirin continues to be the backbone of antiplatelet strategies in cardiovascular secondary prevention. MORE»
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PLAQUE LYMPHANGIOGENESIS: TO DRAIN OR NOT TO DRAIN
Erik A. L. Biessen, Ph.D., Maastricht University, Maastricht, Netherlands
Vulnerable plaques are hallmarked by more pronounced inflammation and neoangiogenesis. Although angiogenesis and lymphangiogenesis are driven by partly overlapping cues, and especially under inflammatory conditions go hand in hand, plaque lymphangiogenesis only in one single earlier report been linked to plaque stability. MORE»
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TICAGRELOR AND STATIN HAVE SYNERGISTIC EFFECTS ON MYOCARDIAL PROTECTION AGAINSY ISCHEMIA-REPERFUSION INJURY
Yochai Birnbaum, M.D., Baylor College of Medicine, Houston, TX, USA
In addition to P2Y12 receptor antagonism, ticagrelor (TIC) inhibits the equilibrative- nucleoside-transporter-1 and thereby, adenosine cell re-uptake. Prior data show that TIC limits infarct size in non-diabetic rats and that the effect is adenosine dependent. MORE»
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PREVENTION OF SUDDEN CARDIAC DEATH: CHALLENGES AND OPPORTUNITIES
Michael Cain, M.D., University at Buffalo, Buffalo, NY, USA
Strategies for prevention of sudden cardiac death in the setting of coronary artery disease rely on implantable cardiac defibrillators (ICD) in a subset of patients with left ventricular ejection fractions <35%. Many ICDs are implanted needlessly. MORE»
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EXERCISE RELATED HYPERTENSION (ERH) MAY NOT BE A BENIGN PHENOMENON
Yzhar Charuzi, M.D., Cedars Sinai Medical Center, LA, USA
Blood Pressure (BP) increases with exercise. However a Systolic BP reaching or exceeding 200mm Hg is considered pathological. We recently observed a 78 years old male who, while walking uphill suddenly noticed loss of speech. MORE» |
PREVENTION AND INTERFERENCE OF ATHEROSCLEROTIC HEART DISEASE IN MULTIPLE ANIMAL MODELS
Subroto Chatterjee, Ph.D., Johns Hopkins University, Baltimore, MD, USA
We previously observed that the level of cholesterol and glycosphingolipids (GSL) rise and fall in tandem upon plasma exchange therapy in patients with LDL receptor negative homozygous familail hypercholesterolemia. MORE»
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BIOMARKERS OF THE FUTURE: METABOLOMIC PREDICTORS OF CARDIOMETABOLIC DISEASE
Susan Cheng, M.D.,
Brigham and Women's Hospital, Boston, MA, USA
By providing information on the diversity of small molecule metabolites in biological systems, current era metabolomics now offer the potential to comprehensively integrate data on both the intrinsic and extrinsic exposures that contribute to complex diseases such as cardiovascular disease. MORE» |
RISK STRATIFICATION AND THERAPY OF ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY
Domenico Corrado, M.D., Ph.D., University of Padova, Italy
Arrhythmogenic Right Ventricular Cardiomyopathy is a genetically determined cardiomyopathy which predisposes to life-threatening ventricular arrhythmias and arrhythmic cardiac arrest. The main goal of clinical management is prevention of sudden cardiac death. MORE» |
IMPROVEMENT IN CLINICAL OUTCOMES WITH BIVENTRICULAR VERSUS RIGHT VENTRICULAR PACING IN THE BLOCK HF STUDY
Anne B. Curtis, M.D., University of Buffalo, Buffalo, NY, USA
Sustained right ventricular (RV) apical pacing may lead to deterioration in ventricular function and an increased risk of heart failure, especially in patients with pre-existing systolic dysfunction. MORE» |
SHORT AND LONG NON-CODING RNAs AS BIOMARKERS OF ACUTE CARDIAC CONDITIONS
Yvan Devaux, Ph.D., Luxembourg Institute of Health, Luxembourg
The first draft of the human genome was published in 2001. However, it is only 10 years later that the ENCODE Int'l Consortium revealed that, while more than 80% of the human genome is transcribed into RNAs, only less than 2% of these RNAs are subsequently translated into proteins. MORE»
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PATHOGENESIS AND THERAPY OF DIABETIC CARDIOMYOPATHY
Naranjan S. Dhalla, Ph.D., M.D. (Hon.), St. Boniface Hospital Albrechtsen Research Centre, University of Manitoba, Winnipeg, MB, Canada
Chronic diabetes is known to be associated with the development of cardiomyopathy, metabolic derangement and cardiac dysfunction. Extensive studies in our laboratory have revealed that cardiac dysfunction due to chronic diabetes is associated with marked alterations in subcellular organelles such as myofibrils, sarcoplasmic reticulum and sarcolemma. MORE» |
CARDIAC IMAGING FOR EVALUATION OF CORONARY ARTERY DISEASE IN PATIENTS WITH HYPERTENSION
Abdou Elhendy, M.D., Ph.D., Marshfield Clinic, Marshfield, WI, USA
Hypertension is a major risk factor for coronary artery disease (CAD) and related morbidity. Identification of an accurate non-invasive method for diagnosis of CAD is important to plan therapeutic and interventional management in order to improve outcome. MORE»
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HIGH-SENSITIVITY ASSAY FOR CARDIAC TROPONIN: NOVEL TOOLS FOR RISK PREDICTION IN AMBULATORY PATIENTS
Brendan M. Everett, M.D., Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Assays for cardiac troponin have become increasingly sensitive, and are now able to detect very low concentrations of circulating cardiac troponin in a substantial proportion of stable patients who are not suspected of having myocardial infarction. MORE» |
CpG DNA REGULATION OF COAGULATION: IMPLICATIONS FOR ACUTE CORONARY ARTERY DISEASE
Janos G. Filep, M.D., University of Montreal, Montreal, Quebec, Canada
Bacteraemia is associated with increased risk of acute coronary artery disease and stroke. Bacterial DNA and mitochondrial DNA, containing unmethylated CpG dinucleotide motifs are potent inducers of immune responses during infection MORE»
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HYPERTENSION UPDATE: QUO VADIMUS?
Zorina S. Galis, Ph.D., Vascular Biology and Hypertension, National Heart Lung and Blood Institute, Bethesda, MD, USA
Hypertension continues to represent a formidable challenge to human health and to healthcare worldwide. Exciting new developments in clinical and fundamental hypertension research are poised to change how we understand and approach the clinical management of hypertension. MORE» |
COMPUTED TOMOGRAPHY ANGIOGRAPHY VS. CORONARY ANGIOGRAPHY: A 3D VESSEL FEATURE COMPARISON AND VALIDATION
Joel Garcia, M.D., Orlando Health, Orlando, FL, USA
Differences in vessel features between computed tomography angiograms (CTA) and coronary angiograms have not been rigorously studied, therefore we sought to validate CTA 3-dimensional (3D) vessel data against coronary angiography MORE»
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ROLE OF ECHOCARDIOGRAPHY IN EPIDEMIOLOGIC STUDIES AND CLINICAL TRIALS: AN HISTORICAL PERSPECTIVE
Julius M. Gardin, M.D., Hackensack University Medical Center, Rutgers New Jersey Medical School, NJ, USA
Non-invasive transthoracic echocardiography (TTE) for assessment of subclinical and clinical heart disease – initially, left ventricular (LV) mass, geometry and function – dates from the 1980’s. In parallel, TTE successfully demonstrated in hypertensive patients reduced LV mass and improved outcomes MORE» |
THYROID HORMONE TREATMENT OF HEART FAILURE: IS THERE A THERAPEUTIC WINDOW?
A. Martin Gerdes, Ph.D., New York Institute of Technology – College of Osteopathic Medicine, Old Westbury, NY, USA
In 1950, a study showed that Thyroid Hormone (TH) treatment significantly reduced cardiovascular mortality and rates of myocardial infarction in three patient groups. Rather than extend these findings, subsequent poorly designed larger clinical studies using toxic doses of TH analogs MORE» |
THE CENTRAL ROLE OF SMOOTH MUSCLE CELL MITOCHONDRIA IN THE PREVENTION OF ABDOMINAL AORTIC ANEURYSM BY LOW LEVEL LASER THERAPY
S. David Gertz, M.D., Ph.D., The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel
We showed, by high frequency ultrasound, that phototherapy with low-level laser, a non-thermal, near-infrared radiation, used widely for reduction of pain and acceleration of wound healing, prevents de novo formation and progression of pre-existing abdominal aortic aneurysm MORE» |
UPDATE ON ASPIRIN IN THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE
Charles H. Hennekens, M.D., Dr.P.H., Florida Atlantic University, Boca Raton, FL, USA
In secondary prevention among a wide range of patients who have survived a prior occlusive vascular event, as well as during acute myocardial infarction and acute occlusive stroke the absolute reductions far exceed the absolute risks. In primary prevention, tbe balance is less clear. MORE»
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IMPACT OF EXERCISE CAPACITY FOR RIGHT AND LEFT HEART FAILURE
Akihiro Hirashiki, M.D., Nagoya University School of Medicine, Nagoya, Japan
Cardiopulmonary exercise testing is a diagnostic tool used to detect serial changes in exercise capacity, and it is of particular benefit for patients with chronic heart failure to assess peak oxygen uptake (peak VO2) and minute ventilation/carbon dioxide production (VE/VCO2) slope. MORE» |
ATRIAL FUNCTIONAL MITRAL REGURGITATION: THE LEFT ATRIUM GETS ITS DUE RESPECT
Brian D. Hoit, M.D., University Hospitals Case Medical Center, Case Western Reserve University. Cleveland, OH, USA
Moderate or greater mitral regurgitation (MR) is the most frequent valve disease in the United States. Competence of the mitral valve requires the temporally and spatially coordinated interaction of the mitral leaflets with the annulus, chordae tendinae, and papillary muscles; MORE»
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INITIAL STAGES OF OBESITY ARE ASSOCIATED WITH INCREASED CARDIOVASCULAR ACTIVATION UNDER STRESS
Daniella Jezova, M.D., Slovak Academy of Sciences, Bratislava, Slovakia
Stress and obesity are well known risk factors for cardiovascular diseases. The recognition of early markers of cardiovascular risk during the development of obesity is essential. The hypothesis tested was that under stress conditions subjects at initial stages of obesity MORE» |
ATRIAL FUNCTIONAL MITRAL REGURGITATION: MACROPHAGE DEPOSITION OF CHOLESTEROL INTO THE EXTRACELLULAR MATRIX - A PATHWAY FOR REVERSE CHOLESTEROL TRANSPORT
Xueting Jin, M.D., National Institutes of Health, Bethesda, Maryland, USA
To investigate the potential for mobilization of extracellular cholesterol within atherosclerotic plaques. Background: Atherosclerotic plaques develop as a result of an imbalance between cholesterol accumulation and cholesterol removal. MORE» |
THE BENEFITS AND RISKS OF LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION; WHERE IS THE POINT OF CLINICAL EQUIPOISE?
Maryl R. Johnson, M.D., University of Wisconsin, Madison, WI, USA
Left ventricular assist devices (LVADs) are used to treat patients with severe heart failure, both as a bridge to transplantation and as destination therapy. However, the best time to proceed with LVAD implantation remains to be determined. MORE» |
AGING AND HEART FAILURE 2016. UPDATE
Bodh I. Jugdutt, M.D., University of Alberta, Edmonton, Alberta, Canada
Concurrent worldwide increases in the aging population and prevalence of heart failure (HF) are accompanied by a parallel increase in the elderly (age = 65 years) with two leading causes of HF, hypertension and myocardial infarction. MORE»
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TRANSITION TO STAGE D HEART FAILURE AMONG STABLE OUTPATIENTS WITH SYSTOLIC HEART FAILURE
Andreas P. Kalogeropoulos, M.D., Ph.D., Emory University, Atlanta, GA, USA
Incidence rates and risk factors for transition to Stage D heart failure (HF) among patients with stable, Stage C HF with reduced ejection fraction have not been described. Methods: We evaluated 3-year transition rates to clinically determined Stage D HF, after accounting for competing mortality, in 919 outpatients MORE» |
TRANSULNAR INTERVENTIONS
Edo Kaluski, M.D., Guthrie Health System, PA, USA
The use of transradial access for diagnostic and therapeutic interventions has dramatically increased in the recent years and has become the preferred approach for coronary angiography and intervention. The ulnar artery is similar in diameter however is somewhat deeper MORE» |
THE ROLE OF ECHOCARDIOGRAPHY IN THE MANAGEMENT OF PATIENTS UNDERGOING VENTRICULAR ASSIST DEVICE IMPLANTATION AND/OR TRANSPLANT SURGERY
Tomoko S. Kato, M.D., Ph.D. , Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan
Heart transplantation (HTx) is a curative treatment for patients with advanced heart failure; however, since transplant opportunity is severely limited due to donor shortage, left ventricular assist device has evolved into a standard therapy for patients awaiting HTx. MORE» |
TREATING FLUID OVERLOAD WITH FLUID; ROLE OF PERITONEAL DIALYSIS IN MANAGEMENT OF HEART FAILURE
Amir Kazory, M.D., University of Florida, Gainesville, Florida, USA
Heart failure (HF) remains the most common reason for hospital admission in older patients resulting in significant burden on healthcare expenditure. The currently available therapeutic modalities for HF do not seem yet to be producing optimal results. MORE» |
THE USE OF POINT OF CARE ULTRASOUND TO GUIDE MANAGEMENT IN HEART FAILURE
Ilan Kedan, M.D., Cedars Sinai Heart Institute, Beverly Hills, CA, USA
Point of Care ultrasound has long been used in the acute care and emergency setting for management of trauma patients. MORE» |
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CARDIOLOGY ONLINE NEWS |
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| 21st WORLD CONGRESS ON HEART DISEASE |
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EDUCATION AND MORTALITY: IS A COLLEGE DEGREE UNIVERSALLY PROTECTIVE?
Arthur L. Klatsky, M.D., Kaiser Permanente Division of Research, Oakland, CA, USA
To study risk of death in relation to educational attainment in 273,843 persons.
Background: Low socio-economic status has been associated with increased incidence of many medical conditions and connected to racial and ethnic health disparities. MORE»
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EFFECT OF ENDOTHELIAL CELL SENESCENCE ON THE HEAT SHOCK RESPONSE AND CELLULAR FUNCTION
Anne. A. Knowlton, M.D., Sacramento VA Medical Center, Mather, CA USA and University of California, Davis, CA, USA
Increasing evidence supports that replicative senescence, cessation of cell division, plays a role in the progression of the aging phenotype. With cellular senescence, cells undergo morphologic, physiologic and functional changes. MORE» |
DOES CYSTATIN SN INFLUENCE ON CYSTATIN C LEVEL IN ISCHEMIA AND PREVIOUS MYOCARDIAL INFARCTION?
Tatiana A. Korolenko, Ph.D., Institute Physiol. Fund. Med., Novosibirsk, Russia
Objectives: To investigate whether patients with ischemic heart disease and previous myocardial infarction (MI) display altered serum cystatin C/cystatin SN ratio. MORE»
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CURRENT STATUS OF INTRAVASCULAR IMAGING
Santhosh K.G. Koshy, M.D., University of Tennessee Health Sciences Center, Memphis TN, USA
Diagnostic angiography has been the mainstay of confirmatory diagnosis of vascular atherosclerosis. Being a luminogram its ability to determine the presence and extent of atherosclerosis is limited by changes in the vessel wall that is adjacent to the atherosclerotic plaque. MORE» |
ROLE OF CVD RISK ASSESSMENT IN COPD
Hwa Mu Lee, M.D., University of California, Irvine, Irvine, CA, USA
Chronic obstructive pulmonary disease is commonly associated with cardiovascular disease since they are both linked with shared factors such as age and smoking history; however, in clinical practice, these two diseases are treated separately. MORE»
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DECIPHERING THE ROLE OF MITOPHAGY IN THE HEART DURING FASTING
Qiangrong Liang, M.D., Ph.D., New York Institute of Technology – College of Osteopathic Medicine, Old Westbury, NY, USA
Alternate-day fasting or starvation is beneficial to the heart, but the underlying mechanism remains speculative. Starvation activates general autophagy, which may contribute to the cardioprotective effect of fasting. MORE»
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AVOIDING AND SOLVING COMPLICATIONS DURING PERCUTANEOUS CLOSURE OF ASD
Avraham Lorber, M.D., Rambam Medical Campus, Haifa, Israel
We present 11 cases of percutaneous transcatheter occlusion of atrial septal defects in adults. These select cases represent an educational approach to special dilemmas, complications, and challenges MORE» |
GLYCOSAMINOGLYCANS (GAGS) IN CARDIOVASCULAR DISEASE: SEARCHING FOR THE SWEET SPOT
Alexandra R. Lucas, M.D., University of Florida, Gainesville, FL, USA
The endothelial glycocalyx alters immune reactions. Among other functions, glycosaminoglycans in the glycocalyx bind chemokines that attract immune cell invasion. MORE»
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TRANSLATING VASCULAR BIOLOGY INTO CLINICAL CARE FOR CARDIOLOGY
Kenneth Maiese, M.D., Rutgers University of Medicine & Dentistry of New Jersey
With the progressing aging of the world’s population, cardiovascular disease will continue to significantly impact millions of individuals throughout the globe. This disorder remains one of five leading causes of death that are cardiac disease, cancer, MORE» |
A NANOMEDICAL APPROACH TO THE RESTORATION OF DYSFUNCTIONAL ENDOTHELIUM AND THE FUNCTION OF THE CARDIOVASCULAR SYSTEM
Tadeusz Malinski, Ph.D., Ohio University, Athens, OH, USA
A dysfunctional endothelium is a common denominator in aging and several cardiovascular diseases: hypertension, diabetes, salt-induced hypertension and atherosclerosis. MORE»
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CLINICAL GENETICS OF DILATED CARDIOMYOPATHY- TESTING WISELY
James D. Marsh, M.D., University of Arkansas for Medical Sciences, Little Rock, AR, USA
Dilated cardiomyopathies (DCM) account for 10,000 deaths/year in the US; African-Americans have a 3-fold increased risk. There has been little solid information available on or the ability to make a precise genetic diagnosis in DCM. MORE» |
WHAT HAPPENS TO THE BRAIN AFTER MYOCARDIAL INFARCTION?
Jawahar L. Mehta, M.D., Ph.D. , University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR, USA
It is assumed, but not proven, that acute myocardial infarction affects function of remote organs- such as kidneys and brain. We examined brain morphology in wild type (WT) mice subjected to left coronary artery (LCA) ligation. MORE» |
OPTIONS FOR REMOTE PATIENT MONITORING IN THE LVAD POPULATION
Dan M. Meyer, M.D., Methodist Health System, Dallas, Texas, USA
Multiple technologies are emerging that may have roles in remote patient monitoring in the LVAD population. These include smartphone applications and wearables, nanosensors, lab-on-a-chip platforms, and miniaturized systems. MORE»
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SECONDARY PREVENTION OF CARDIOVASCULAR EVENTS
Samia Mora, M.D., Brigham and Women's Hospital, Boston, MA, USA
Cardiovascular risk among individuals with manifest cardiovascular disease remains high and has been termed “residual risk”. Results from a meta-analysis of statin trials involving 90,056 individuals found that the rate of a major vascular event MORE»
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UPDATE ON CONTRAST REMOVAL FROM CORONARY SINUS DURING CORONARY ANGIOGRAPHY OR INTERVENTION FOR PREVENTION OF CONTRAST INDUCED NEPHROPATHY
Mohammad-Reza Movahed, M.D., Ph.D., CareMore, Tucson, Arizona, University of Arizona College of Medicine, USA
Contrast usage during coronary angiography or intervention in patients with renal disease is associated with substantial risk of contrast induced nephropathy that can lead to higher mortality, longer hospital stay and substantial cost. MORE»
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CAN GDF-15 BE USED AS A BIOMARKER IN DILATED CARDIOMYOPATHY
Nandini Nair, M.D., Ph.D., Texas Tech HSC, Lubbock, TX, USA
Growth and Differentiation Factor-15 (GDF-15) has been found to play an important role in fibrosis, inflammation and ventricular remodeling. The role of GDF-15 in regulation of cardiac remodeling in idiopathic dilated cardiomyopathy is less well-defined. MORE» |
INNOVATIVE P-WAVE DETECTION FOR DISCRIMINATION BETWEEN VENTRICULAR AND SUPRAVENTRICULAR TACHYCARDIA IN SINGLE-CHAMBER ICDS: IS THE P-WAVE INVISIBLE DURING TACHYCARDIA?
Hakan Paydak, M.D. , UAMS, Little Rock, AR, USA
Differentiation between supraventricular tachycardia and ventricular tachycardia remains a substantial clinical challenge in patients with single-chamber implantable cardioverter-defibrillators due to absence of visible P waves. MORE»
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LOW GRADIENT SEVERE AORTIC STENOSIS: ECHO FEATURES AND CLINICAL SIGNIFICANCE
Patricia A. Pellikka, M.D., Mayo Clinic, Rochester, MN, USA
Current practice guidelines define severe aortic stenosis (AS) as aortic valve (AV) area less than1 cm2 and mean AV gradient greater than 40 mmHg. Low gradient severe AS refers to the condition of mismatch between an AV area which suggests severe AS and mean gradient MORE» |
VALVE PROSTHESIS-PATIENT MISMATCH (VP-PM): A LONG-TERM PERSPECTIVE
Shahbudin H. Rahimtoola, M.D., University of Southern California, Los Angeles, CA, USA
VP- PM was first described in 1978 by Rahimtoola. From that time to 2011, aortic VP-PM has received a great deal of attention but studies have come to varying conclusions especially with regard to its effect on mortality. MORE»
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OSTEOGENIC DIFFERENTIATION IS A MECHANISM FOR BIOPROSTHETIC VALVE CALCIFICATION
Nalini M. Rajamannan, M.D., Mayo Clinic, Rochester, MN, USA
Bioprosthetic heart valve calcification is the major cause of structural valve deterioration (SVD). The mechanism of valve degeneration is unknown. This study hypothesizes that bioprosthetic valve calcification is a stem cell mediated bone differentiation process. MORE» |
THE HIGHLY DIFFICULT LIPOPROTEIN: CONTROVERSIES AND NEW DIRECTIONS
Robert S. Rosenson, Ph.D., Icahn School of Medicine at Mount Sinai, New York, NY, USA
Classical epidemiology has established the incremental contribution of the high density lipoprotein (HDL) cholesterol measure in the assessment of atherosclerotic cardiovascular disease risk; however, genetic epidemiology does not support a causal relationship between HDL cholesterol and future risk of myocardial infarction. MORE» |
CXCR6/CXCL16 AXIS IS INVOLVED IN MONONUCLEAR CELL ADHESION INDUCED BY ANGIOTENSIN II, POTENTIAL IMPLICATION IN ABDOMINAL AORTIC ANEURYSM (AAA) FORMATION?
Maria J. Sanz, Ph.D., Faculty of Medicine, University of Valencia, Valencia, Spain
Abdominal aortic aneurysm is a degenerative disease of the aorta that mainly affects elderly population over the age of 65. Nowadays the pathways involved in its onset and progression remain unknown and angiotensin-II has been widely implicated. MORE» |
CARDIOVASCULAR EFFECTS OF CARFILZOMIB, A NEW PROTEASOME INHIBITOR, ON CORONARY ARTERY RESISTANCE, VASCULAR TONE AND VASCULAR REACTIVITY
Tiziano M. Scarabelli, M.D., The University of Alabama at Birmingham, Birmingham, AL, USA
Carfilzomib is a proteasome inhibitor which was recently approved in the United States as a single agent for the treatment of patients with relapsed and refractory Multiple Myeloma. Chemically it is a tetrapeptide epoxyketone and an analog of epoxomicin. MORE»
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COMPARISON OF EARLY HEMODYNAMIC PERFORMANCE OF STENTED PERICARDIAL AND PORCINE AORTIC VALVES
Rakesh K. Sharma, M.D., University of Utah, Salt Lake City, UT, USA
Data comparing the hemodynamic performance of stented pericardial and porcine aortic valves are conflicting. We performed a systematic review and meta-analysis comparing the early hemodynamic parameters of stented pericardial and porcine valves in patients undergoing isolated aortic valve replacement. MORE» |
ASTHMA AS A RISK FACTOR OF HUMAN AND EXPERIMENTAL ABDOMINAL AORTIC ANEURYSM
Guo-Ping Shi, SC.D., D.SC., Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
Asthma and abdominal aortic aneurysms (AAA) both involve inflammation. It remains unknown whether these diseases interact. MORE»
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THE CANCER ASSOCIATED FIBROBLAST AND THE HEART FAILURE ASSOCIATED FIBROBLAST- SIMILAR PHENOTYPE, SIMILAR PATHWAYS LEADING TO POTENTIALLY SIMILAR TREATMENT
Francis G. Spinale, Ph.D., M.D., USC School of Medicine and WJB Dorn VA, Columbia, SC, USA
While morbidity, mortality, and health care costs associated with heart failure (HF) are increasing, advancements in early diagnosis and treatment strategies have not been forthcoming. Firstly, there is a need to differentiate HF phenotypes into different disease processes MORE» |
RISK STRATIFICATION IN BRUGADA SYNDROME: ICD INDICATION IN PATIENTS WITHOUT HISTORY OF CARDIAC ARREST
Masahiko Takagi, M.D., Ph.D., Osaka City Graduate School of Medicine, Osaka, Japan
Risk assessment in patients without previous documented VF or aborted sudden death (SCD) is not yet fully established. Indication for implantable cardioverter defibrillator in Brugada patients without documented VF or SCD is classified as Class II or III indication. MORE»
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OPTIMUM TREATMENT OF ANGINA PECTORIS SHOULD TAKE INTO CONSIDERATION PATIENTS’ CIRCULATORY STATUS AND THE PRESENCE OF ASSOCIATED COMORBIDITIES IN THE YEAR 2016
Udho Thadani, M.D., M.D., OU Medical Center and VA Medical Center, Oklahoma City, Oklahoma, USA
Currently many treatment options, including medicines, and revascularization procedures are available to treat patients with stable angina pectoris. All patients with angina pectoris due to underlying CAD should be treated with a low dose aspirin and a high dose, potent statin, if tolerated, MORE» |
PREVENTION OF ACUTE MI BY AGGRESSIVE APPROACH TO TREAT UNSTABLE ANGINA
Yasunori Ueda, M.D., Ph.D., Osaka National Hospital, Osaka, Japan
Although the incidence of in-hospital death from acute myocardial infarction (MI) is about 5%, about 40% of the patients who suffer acute MI die before hospitalization. MORE»
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THE ROLE OF HEMODYNAMIC SUPPORT IN THE MANAGEMENT OF AMI WITH SHOCK
George W. Vetrovec, M.D., VCU Medical Center Richmond, Virginia USA
Outcomes for Acute Myocardial Infarction have improved significantly with acute Percutaneous Coronary Intervention. However, the incidence of associated cardiogenic shock has increased and remains a major cause of death. MORE» |
SEX DIFFERENCES IN THE CARDIOVASCULAR CONSEQUENCES OF DIABETES MELLITUS
Nanette K. Wenger, M.D., Emory University School of Medicine, Atlanta, GA, USA
Cardiovascular disease is the leading cause of morbidity and mortality with type 2 diabetes mellitus, accounting for > 75% of hospitalizations and >5% of deaths. Women have a 3-fold excess of coronary heart disease risk compared to men MORE»
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EFFICACY OF A CARDIOVASCULAR BEHAVIORAL INTERVENTION PROGRAM ON PROGRESSION OF ATHEROSCLEROSIS
Nathan D. Wong, Ph.D., University of California, Irvine, CA, USA
Limited data exist on the efficacy of multifactorial lifestyle programs on impacting the progression of atherosclerosis. We examined the efficacy of a lifestyle intervention program on progression of coronary artery calcium. MORE» |
WHOLE HEART REGENERATION WITH HUMAN iPS CELL-DERIVED HEART PROGENITORS
Lei Yang, Ph.D., University of Pittsburgh, Pittsburgh, PA, USA
In US, about 50,000 people die each year due to the limited donor hearts for transplant. Thus the future treatment of heart disease requires the development of personalized therapeutic strategies, such as patient-specific cardiac tissues or whole bio-artificial hearts for transplantation. MORE»
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